abstract：BACKGROUND:Pheochromocytoma (PCC) and paraganglioma (PGL) are uncommon neoplasms with high morbidity in advanced stages. Effective systemic treatments are limited. METHODS:A multisite phase 2 trial evaluated sunitinib in patients with progressive PCC/PGL. Patients received 50 mg orally for 4-6 weeks. RESULTS:Between ...

journal_title：British journal of cancer

authors： O'Kane GM,Ezzat S,Joshua AM,Bourdeau I,Leibowitz-Amit R,Olney HJ,Krzyzanowska M,Reuther D,Chin S,Wang L,Brooks K,Hansen AR,Asa SL,Knox JJ

更新日期：2019-06-01 00:00:00

abstract：:Oesophageal adenocarcinoma has become much more common over the past 50 years, particularly in Britain, with an unexplained male to female ratio of > 4:1. Given the use of asbestos filtration in commercial brewing and reports of its unregulated use in British public houses in the 1970's to clear draught beer "slops", ...

journal_title：British journal of cancer

authors： Fitzgerald RC,Rhodes JM

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Previous studies have reported up to 50% of ductal carcinoma in situ (DCIS), is HER2 positive, but the frequency of HER2-positive invasive breast cancer (IBC) is lower. The aim of this study is to characterise HER2 status in DCIS and assess its prognostic value. METHODS:HER2 status was evaluated in a large ...

journal_title：British journal of cancer

authors： Miligy IM,Toss MS,Gorringe KL,Lee AHS,Ellis IO,Green AR,Rakha EA

更新日期：2019-05-01 00:00:00

abstract：:Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques-including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imagin...

journal_title：British journal of cancer

authors： Beaton L,Bandula S,Gaze MN,Sharma RA

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Among patients with cancer, prior research suggests that patients with mental illness may have reduced survival. The objective was to assess the impact of psychiatric utilisation (PU) prior to cancer diagnosis on survival outcomes. METHODS:All residents of Ontario diagnosed with one of the top 10 malignanci...

journal_title：British journal of cancer

authors： Klaassen Z,Wallis CJD,Goldberg H,Chandrasekar T,Sayyid RK,Williams SB,Moses KA,Terris MK,Nam RK,Urbach D,Austin PC,Kurdyak P,Kulkarni GS

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Ezrin, which is known as a cytoskeleton linker protein, is closely linked with the metastatic progression of cancer and is frequently abnormally expressed in aggressive cancer types. However, the possible involvement of Ezrin in metastasis and angiogenesis in breast cancer remains unclear. METHODS:Immunohis...

journal_title：British journal of cancer

authors： Li N,Kong J,Lin Z,Yang Y,Jin T,Xu M,Sun J,Chen L

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Placental-site trophoblastic (PSTT) and epithelioid trophoblastic tumours (ETT) are the rarest malignant forms of gestational trophoblastic disease (GTD). Our prior work demonstrated that an interval of ≥48 months from the antecedent pregnancy was associated with 100% death rate, independent of the stage. He...

journal_title：British journal of cancer

authors： Froeling FEM,Ramaswami R,Papanastasopoulos P,Kaur B,Sebire NJ,Short D,Fisher RA,Sarwar N,Wells M,Singh K,Ellis L,Horsman JM,Winter MC,Tidy J,Hancock BW,Seckl MJ

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Emergence of drug-resistant cancer phenotypes is a challenge for anti-cancer therapy. Cancer stem cells are identified as one of the ways by which chemoresistance develops. METHOD:We investigated the anti-inflammatory combinatorial treatment (DA) of doxorubicin and aspirin using a preclinical microfluidic m...

journal_title：British journal of cancer

authors： Khoo BL,Grenci G,Lim JSY,Lim YP,Fong J,Yeap WH,Bin Lim S,Chua SL,Wong SC,Yap YS,Lee SC,Lim CT,Han J

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:This phase 1 study examined the safety, tolerability, pharmacokinetics and preliminary efficacy of eribulin-liposomal formulation (eribulin-LF) in patients with advanced solid tumours. METHODS:Eligible patients with ECOG PS 0-1 were treated with eribulin-LF either on day 1 every 21 days (Schedule 1), or on ...

journal_title：British journal of cancer

authors： Evans TRJ,Dean E,Molife LR,Lopez J,Ranson M,El-Khouly F,Zubairi I,Savulsky C,Reyderman L,Jia Y,Sweeting L,Greystoke A,Barriuso J,Kristeleit R

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Heterogeneity and low incidence comprise the biggest challenge in sarcoma diagnosis and treatment. Chemotherapy, although efficient for some sarcoma subtypes, generally results in poor clinical responses and is mostly recommended for advanced disease. Specific genomic aberrations have been identified in some...

journal_title：British journal of cancer

authors： Brodin BA,Wennerberg K,Lidbrink E,Brosjö O,Potdar S,Wilson JN,Ma L,Moens LN,Hesla A,Porovic E,Bernhardsson E,Papakonstantinou A,Bauer H,Tsagkozis P,von Sivers K,Wejde J,Östling P,Kallioniemi O,Stragliotto CL

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is currently the best predictor of responsiveness towards immune checkpoint blockade. Data about the prevalence of high-level microsatellite instability in cholangiocarc...

journal_title：British journal of cancer

authors： Goeppert B,Roessler S,Renner M,Singer S,Mehrabi A,Vogel MN,Pathil A,Czink E,Köhler B,Springfeld C,Pfeiffenberger J,Rupp C,Weiss KH,Schirmacher P,von Knebel Doeberitz M,Kloor M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:There are phase 3 clinical trials underway evaluating anti-PD-L1 antibodies as adjuvant (postoperative) monotherapies for resectable renal cell carcinoma (RCC) and triple-negative breast cancer (TNBC); in combination with antiangiogenic VEGF/VEGFR2 inhibitors (e.g., bevacizumab and sunitinib) for metastatic ...

journal_title：British journal of cancer

authors： Wu FTH,Xu P,Chow A,Man S,Krüger J,Khan KA,Paez-Ribes M,Pham E,Kerbel RS

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cancer cachexia is a complex wasting syndrome affecting patients with advanced cancer, with systemic inflammation as a key component in pathogenesis. Protein degradation and release of amino acids (AAs) in skeletal muscle are stimulated in cachexia. Here, we define factors contributing to serum AA levels in ...

journal_title：British journal of cancer

authors： Sirniö P,Väyrynen JP,Klintrup K,Mäkelä J,Karhu T,Herzig KH,Minkkinen I,Mäkinen MJ,Karttunen TJ,Tuomisto A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The National Comprehensive Cancer Network (NCCN) guidelines provide recommendations for staging of prostate cancer patients in the objective regarding presence of locoregional lymph node metastases (LNM) and bone metastases. We tested the performance characteristics of these recommendations in a community se...

journal_title：British journal of cancer

authors： Preisser F,Mazzone E,Nazzani S,Marchioni M,Bandini M,Tian Z,Saad F,Soulières D,Shariat SF,Montorsi F,Huland H,Graefen M,Tilki D,Karakiewicz PI

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Extracellular matrix (ECM) plays a crucial role in tumour behaviour. Prolyl-4-hydroxlase-A2 (P4HA2) is a key enzyme in ECM remodelling. This study aims to evaluate the prognostic significance of P4HA2 in breast ductal carcinoma in situ (DCIS). METHODS:P4HA2 expression was assessed immunohistochemically in m...

journal_title：British journal of cancer

authors： Toss MS,Miligy IM,Gorringe KL,AlKawaz A,Khout H,Ellis IO,Green AR,Rakha EA

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Cancer prognostic biomarkers have shown disappointing clinical applicability. The objective of this study was to classify and estimate how study results are overinterpreted and misreported in prognostic factor studies in oncology. METHODS:This systematic review focused on 17 oncology journals with an impact...

journal_title：British journal of cancer

authors： Kempf E,de Beyer JA,Cook J,Holmes J,Mohammed S,Nguyên TL,Simera I,Trivella M,Altman DG,Hopewell S,Moons KGM,Porcher R,Reitsma JB,Sauerbrei W,Collins GS

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:We assessed the association between symptoms reported at breast cancer screening visits and interval cancers (ICs) in a prospective manner. METHODS:This population-based matched cohort study uses data of the Finnish National Breast Cancer Screening Programme that invites women aged 50-69 years old during 19...

journal_title：British journal of cancer

authors： Singh D,Miettinen J,Duffy S,Malila N,Pitkäniemi J,Anttila A

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A. METHODS:Autophagy substrates...

journal_title：British journal of cancer

authors： Kaliszczak M,van Hechanova E,Li Y,Alsadah H,Parzych K,Auner HW,Aboagye EO

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:We modified and evaluated an advance care planning (ACP) intervention, which had been shown to improve compliance with patient's end of life (EoL) wishes, in a different patient population. METHODS:Patients with incurable cancer, and a Family Member (FM), were randomised one-to-one to usual care or usual ca...

journal_title：British journal of cancer

authors： Johnson SB,Butow PN,Bell ML,Detering K,Clayton JM,Silvester W,Kiely BE,Clarke S,Vaccaro L,Stockler MR,Beale P,Fitzgerald N,Tattersall MHN

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. METHODS:A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chron...

journal_title：British journal of cancer

authors： Cordani M,Butera G,Dando I,Torrens-Mas M,Butturini E,Pacchiana R,Oppici E,Cavallini C,Gasperini S,Tamassia N,Nadal-Serrano M,Coan M,Rossi D,Gaidano G,Caraglia M,Mariotto S,Spizzo R,Roca P,Oliver J,Scupoli MT,Donad

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:There is growing evidence that history of allergic or autoimmune disease is associated with reduced risk of glioma, but few prospective studies have explored the biological basis. To assess associations with immune conditions and levels of 14 cytokines in serial prediagnostic serum samples, we conducted a st...

journal_title：British journal of cancer

authors： Brenner AV,Inskip PD,Rusiecki J,Rabkin CS,Engels J,Pfeiffer RM

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:New prognostic markers are needed to identify patients with Ewing sarcoma (EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the incidence and association with outcome of circulating tumour DNA (ctDNA) using next-generation sequencing (NGS) assays. METHODS:A NGS hybrid capture ass...

journal_title：British journal of cancer

authors： Shulman DS,Klega K,Imamovic-Tuco A,Clapp A,Nag A,Thorner AR,Van Allen E,Ha G,Lessnick SL,Gorlick R,Janeway KA,Leavey PJ,Mascarenhas L,London WB,Vo KT,Stegmaier K,Hall D,Krailo MD,Barkauskas DA,DuBois SG,Crompton B

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:This study was done to investigate the long-term event free and overall survival of high-dose chemotherapy followed by autologous stem cell transplantation (ASCT), compared to maintenance chemotherapy (MT). Patterns of recurrences and late sequelae of both arms were analysed. METHODS:A randomised open label...

journal_title：British journal of cancer

authors： Berthold F,Ernst A,Hero B,Klingebiel T,Kremens B,Schilling FH,Simon T

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Tumour carbonic anhydrase IX (CAIX), a hypoxia-inducible tumour-associated cell surface enzyme, is thought to acidify the tumour microenvironment by hydrating CO2 to form protons and bicarbonate, but there is no definitive evidence for this in solid tumours in vivo. METHODS:We used 1H magnetic resonance spe...

journal_title：British journal of cancer

authors： Lee SH,McIntyre D,Honess D,Hulikova A,Pacheco-Torres J,Cerdán S,Swietach P,Harris AL,Griffiths JR

更新日期：2018-08-01 00:00:00

abstract：:Supplementary Table 1 and the Supplementary Figure legends were not included when this manuscript was first published. The files are now available here. ...

journal_title：British journal of cancer

authors： Lièvre A,Ouine B,Canet J,Cartier A,Amar Y,Cacheux W,Mariani O,Guimbaud R,Selves J,Lecomte T,Guyetant S,Bieche I,Berger F,de Koning L

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). METHODS:We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years....

journal_title：British journal of cancer

authors： Cho A,Chang Y,Ahn J,Shin H,Ryu S

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:In colorectal cancer (CRC), BRAF mutations influence tumour progression. In mismatch repair-deficient (dMMR) tumours, BRAF mutations are associated with a good prognosis, whereas in MMR-competent tumours, they are detrimental. The differential expression of the downstream MAPK pathway members, which are cons...

journal_title：British journal of cancer

authors： Roseweir AK,Halcrow ES,Chichilo S,Powell AG,McMillan DC,Horgan PG,Edwards J

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Uncertainty remains about the associations of adiposity with intestinal cancer in China and by its anatomical subtype. METHODS:The prospective China Kadoorie Biobank recorded 3024 incident cases of colorectal (CRC) and 143 cases of small intestine (SIC) cancer during a 10-year follow-up among 509 568 partic...

journal_title：British journal of cancer

authors： Pang Y,Kartsonaki C,Guo Y,Chen Y,Yang L,Bian Z,Bragg F,Millwood IY,Mao E,Li Y,Shi L,Chen J,Li L,Holmes MV,Chen Z

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is mainly related to human papillomavirus (HPV) infection. As OPSCCs are often diagnosed at an advanced stage, mortality and morbidity remain high. There are no diagnostic biomarkers for early detection of OPSCC. METHODS:Serum from 25...

journal_title：British journal of cancer

authors： Tuhkuri A,Saraswat M,Mäkitie A,Mattila P,Silén R,Dickinson A,Carpén T,Tohmola T,Joenväärä S,Renkonen S

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Prescribing anti-programmed death-1 (PD-1) immunotherapy for advanced melanoma is currently not restricted by any biomarker assessment. Determination of programmed death-ligand-1 (PD-L1)-expression status is technically challenging and is not mandatory, because negative tumours also achieve therapeutic respo...

journal_title：British journal of cancer

authors： Dupuis F,Lamant L,Gerard E,Torossian N,Chaltiel L,Filleron T,Beylot-Barry M,Dutriaux C,Prey S,Gros A,Jullie ML,Meyer N,Vergier B

更新日期：2018-07-01 00:00:00

abstract：:The author Sara Lonardi was incorrectly listed as Sara Leonardi. The correct name is listed above. ...

journal_title：British journal of cancer

authors： Rampazzo E,Del Bianco P,Bertorelle R,Boso C,Perin A,Spiro G,Bergamo F,Belluco C,Buonadonna A,Palazzari E,Lonardi S,De Paoli A,Pucciarelli S,De Rossi A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:While lung adenocarcinoma patients can somewhat benefit from anti-angiogenic therapies, patients with squamous cell lung carcinoma (SQLC) cannot. The reasons for this discrepancy remain largely unknown. Soluble VEGF receptor-1, namely sVEGFR1-i13, is a truncated splice variant of the cell membrane-spanning V...

journal_title：British journal of cancer

authors： Abou Faycal C,Brambilla E,Agorreta J,Lepeltier N,Jacquet T,Lemaître N,Emadali A,Lucas A,Lacal PM,Montuenga L,Pio R,Gazzeri S,Eymin B

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Chromosomal instability (CIN) is a common trait of cancer characterised by the continuous gain and loss of chromosomes during mitosis. Excessive levels of CIN can suppress tumour growth, providing a possible therapeutic strategy. The Mps1/TTK kinase has been one of the prime targets to explore this concept, ...

journal_title：British journal of cancer

authors： Maia ARR,Linder S,Song JY,Vaarting C,Boon U,Pritchard CEJ,Velds A,Huijbers IJ,van Tellingen O,Jonkers J,Medema RH

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Chemerin, a known chemoattractant, participates in multiple biological events. However, its role in cancer remains largely unknown. METHODS:Chemerin expression was evaluated by real-time PCR, western blot and immunohistochemistry. Forced expression, RNAi, immunoprecipitation, etc. were used in function and ...

journal_title：British journal of cancer

authors： Li JJ,Yin HK,Guan DX,Zhao JS,Feng YX,Deng YZ,Wang X,Li N,Wang XF,Cheng SQ,Bao Y,Xie D

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Systemic failure remains a challenge in rectal cancer. We investigated the possible systemic anti-tumour immune activity invoked within oxaliplatin-based neoadjuvant therapy. METHODS:In two high-risk patient cohorts, we assessed the circulating levels of the fms-like tyrosine kinase 3 ligand (Flt3L), a fact...

journal_title：British journal of cancer

authors： Kalanxhi E,Meltzer S,Schou JV,Larsen FO,Dueland S,Flatmark K,Jensen BV,Hole KH,Seierstad T,Redalen KR,Nielsen DL,Ree AH

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours. ME...

journal_title：British journal of cancer

authors： Cortes J,Tamura K,DeAngelo DJ,de Bono J,Lorente D,Minden M,Uy GL,Kantarjian H,Chen LS,Gandhi V,Godin R,Keating K,McEachern K,Vishwanathan K,Pease JE,Dean E

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogeneous MNA (hetMNA). Prognostication and therapy allocation are still uns...

journal_title：British journal of cancer

authors： Berbegall AP,Bogen D,Pötschger U,Beiske K,Bown N,Combaret V,Defferrari R,Jeison M,Mazzocco K,Varesio L,Vicha A,Ash S,Castel V,Coze C,Ladenstein R,Owens C,Papadakis V,Ruud E,Amann G,Sementa AR,Navarro S,Ambros PF

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Veliparib is a potent poly(ADP-ribose) polymerase inhibitor. This phase 1 study aimed to establish the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of veliparib combined with various FOLFIRI regimens in patients with solid tumours. METHODS:Patients received veliparib (10-270 mg BID, days...

journal_title：British journal of cancer

authors： Berlin J,Ramanathan RK,Strickler JH,Subramaniam DS,Marshall J,Kang YK,Hetman R,Dudley MW,Zeng J,Nickner C,Xiong H,Komarnitsky P,Shepherd SP,Hurwitz H,Lenz HJ

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS:We pooled data from 39 Ovarian Cancer Association Con...

journal_title：British journal of cancer

authors： Dixon-Suen SC,Nagle CM,Thrift AP,Pharoah PDP,Ewing A,Pearce CL,Zheng W,Australian Ovarian Cancer Study Group.,Chenevix-Trench G,Fasching PA,Beckmann MW,Lambrechts D,Vergote I,Lambrechts S,Van Nieuwenhuysen E,Rossing MA,Do

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Sequence variations in coding and non-coding regions of the genome can affect gene expression and signalling pathways, which in turn may influence disease outcome. METHODS:In this study, we integrated somatic mutations, gene expression and clinical data from 930 breast cancer patients included in the TCGA d...

journal_title：British journal of cancer

authors： Győrffy B,Pongor L,Bottai G,Li X,Budczies J,Szabó A,Hatzis C,Pusztai L,Santarpia L

更新日期：2018-04-01 00:00:00